Now, if you like what you read or you have any extra questions, you can book a free online meeting to discuss your project with our consultants. Tell us about your project and we will get the correct consultant for you.
Discover the epigenetic factors influencing gene expression and function. Our versatile epigenomics services, such as whole genome bisulfite sequencing, targeted methylation-capture sequencing and ChIP sequencing can help you analyze DNA methylation and study the interactions between DNA and histone proteins.
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Now, if you like what you read or you have any extra questions, you can book a free online meeting to discuss your project with our consultants. Tell us about your project and we will get the correct consultant for you.
Epigenome sequencing can help you elucidate the complex role between external environmental factors and gene expression. DNA methylation and DNA–histone interactions are among the most commonly studied epigenetic control mechanisms for gene transcription and these processes can be analyzed effectively with next generation sequencing (NGS).
As with both genome and RNA sequencing, epigenome sequencing can be done for an entire genome or in a targeted manner. Whole genome bisulfite sequencing (WGBS) is a method of measuring the degree of DNA methylation across the genome. It works by treating DNA with sodium bisulfite, which converts nonmethylated cytosine to uracil, and analyzing the sequence.
Targeted, or methyl-capture, sequencing is a method that focuses on the most relevant sections of the genome from a methylation perspective. These sections include CpG islands – often found in promoter regions – and other known differentially methylated regions (DMRs). DNA from these regions is selectively captured, bisulfite treated and sequenced.
Chromatin immunoprecipitation (ChIP) sequencing specifically analyzes DNA fragments based on their interaction with proteins. It works by fragmenting DNA while keeping the DNA–protein bonds intact, and then isolating relevant DNA fragments by capturing a protein of interest. Sequencing and mapping of the captured fragments provides insights into that protein’s role within the genome.
Now, if you like what you read or you have any extra questions, you can book a free online meeting to discuss your project with our consultants. Tell us about your project and we will get the correct consultant for you.
Now, if you like what you read or you have any extra questions, you can book a free online meeting to discuss your project with our consultants. Tell us about your project and we will get the correct consultant for you.
You can have a look to the list of all library kits available and the Macrogen Europe sample criteria. RTR samples? You can also find the library criteria in case your sample are ready for sequencing.
Do you need to know the methylation matter in human or mousse? Our partnership with Agilent allows us to provide library kits for both. Our variety of library kits, thanks to Illumina and other lead providers, cover any project needs you might have. Have a look at our top selling kits for Epigenome Sequencing
Now, if you like what you read or you have any extra questions, you can book a free online meeting to discuss your project with our consultants. Tell us about your project and we will get the correct consultant for you.
You can have a look to the list of all library kits available and the Macrogen Europe sample criteria. RTR samples? You can also find the library criteria in case your sample are ready for sequencing.
Now, if you like what you read or you have any extra questions, you can book a free online meeting to discuss your project with our consultants. Tell us about your project and we will get the correct consultant for you
Now, if you like what you read or you have any extra questions, you can book a free online meeting to discuss your project with our consultants. Tell us about your project and we will get the correct consultant for you.
You can have a look to the list of all library kits available and the Macrogen Europe sample criteria. RTR samples? You can also find the library criteria in case your sample are ready for sequencing.
Knowing the purpose of your research is essential to establish the correct sequencing configuration and statistic analysis. Let us know what is the objective of your research and we will guide you in getting the correct bioinformatics services.
For most researchers obtaining RAW data is sufficiet for their research. However, Macrogen Europe is also ready to provide bioinformatics analysis for your project.
We are working to provide you with some examples of the type of graphs and analysis for Epigenome Sequencing.
Knowing the purpose of your research is essential to establish the correct sequencing configuration and statistic analysis. Let us know what is the objective of your research and we will guide you in getting the correct bioinformatics services.